Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy
Identifieur interne : 000734 ( Main/Exploration ); précédent : 000733; suivant : 000735Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy
Auteurs : Lei Shi [République populaire de Chine] ; Jun Fang [Japon]Source :
- Journal of Experimental & Clinical Cancer Research : CR [ 0392-9078 ] ; 2008.
Abstract
High expression of the inducible isoform of heme oxygenase (HO-1) is well known in various solid tumors in human and experimental animal models. To investigate the relationship between HO-1 and nasopharyngeal carcinomas, especially its involvement in the response of nasopharyngeal carcinomas to radiotherapy, thirty-two nasopharyngeal carcinomas were semi-quantitatively analyzed by RT-PCR, and the expression of HO-1 was correlated with the consequence after novel radiotherapy, which was evaluated by the reduction of tumor size. Among 32 nasopharyngeal carcinomas, HO-1 expression was found in19 samples (59.4%), in which 9 patients (47.4%) showed no response to radiotherapy. Interestingly, in 13 nasopharyngeal carcinoma patients with negative expression of HO-1, radiotherapy exhibited to be effective (9 patients, 69.2%) or responsive (3 patients, 23.1%). In this study, we first demonstrated the expression of HO-1 in nasopharyngeal carcinomas, and more important, these findings strongly suggest the potential of HO-1as a useful index in identifying patients with well response to radiotherapy, further these data indicate a new therapeutic for nasopharyngeal carcinoma by inhibiting HO-1 activity, which warrants further investigation.
Url:
DOI: 10.1186/1756-9966-27-13
PubMed: 18582367
PubMed Central: 2486265
Affiliations:
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China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Otorhinolaryngology, the first affiliated hospital of China Medical University, Shenyang, 110001</wicri:regionArea><wicri:noRegion>110001</wicri:noRegion></affiliation></author><author><name sortKey="Fang, Jun" sort="Fang, Jun" uniqKey="Fang J" first="Jun" last="Fang">Jun Fang</name><affiliation wicri:level="1"><nlm:aff id="I2">Laboratory of Microbiology & Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Microbiology & Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082</wicri:regionArea><wicri:noRegion>Kumamoto 860-0082</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18582367</idno><idno type="pmc">2486265</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486265</idno><idno type="RBID">PMC:2486265</idno><idno type="doi">10.1186/1756-9966-27-13</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000251</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000251</idno><idno type="wicri:Area/Pmc/Curation">000250</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000250</idno><idno type="wicri:Area/Pmc/Checkpoint">000343</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000343</idno><idno type="wicri:Area/Ncbi/Merge">000081</idno><idno type="wicri:Area/Ncbi/Curation">000081</idno><idno type="wicri:Area/Ncbi/Checkpoint">000081</idno><idno type="wicri:doubleKey">0392-9078:2008:Shi L:implication:of:heme</idno><idno type="wicri:Area/Main/Merge">000740</idno><idno type="wicri:Area/Main/Curation">000734</idno><idno type="wicri:Area/Main/Exploration">000734</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy</title><author><name sortKey="Shi, Lei" sort="Shi, Lei" uniqKey="Shi L" first="Lei" last="Shi">Lei Shi</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Otorhinolaryngology, the first affiliated hospital of China Medical University, Shenyang, 110001, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Otorhinolaryngology, the first affiliated hospital of China Medical University, Shenyang, 110001</wicri:regionArea><wicri:noRegion>110001</wicri:noRegion></affiliation></author><author><name sortKey="Fang, Jun" sort="Fang, Jun" uniqKey="Fang J" first="Jun" last="Fang">Jun Fang</name><affiliation wicri:level="1"><nlm:aff id="I2">Laboratory of Microbiology & Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Microbiology & Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082</wicri:regionArea><wicri:noRegion>Kumamoto 860-0082</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Experimental & Clinical Cancer Research : CR</title><idno type="ISSN">0392-9078</idno><idno type="eISSN">1756-9966</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>High expression of the inducible isoform of heme oxygenase (HO-1) is well known in various solid tumors in human and experimental animal models. To investigate the relationship between HO-1 and nasopharyngeal carcinomas, especially its involvement in the response of nasopharyngeal carcinomas to radiotherapy, thirty-two nasopharyngeal carcinomas were semi-quantitatively analyzed by RT-PCR, and the expression of HO-1 was correlated with the consequence after novel radiotherapy, which was evaluated by the reduction of tumor size. Among 32 nasopharyngeal carcinomas, HO-1 expression was found in19 samples (59.4%), in which 9 patients (47.4%) showed no response to radiotherapy. Interestingly, in 13 nasopharyngeal carcinoma patients with negative expression of HO-1, radiotherapy exhibited to be effective (9 patients, 69.2%) or responsive (3 patients, 23.1%). In this study, we first demonstrated the expression of HO-1 in nasopharyngeal carcinomas, and more important, these findings strongly suggest the potential of HO-1as a useful index in identifying patients with well response to radiotherapy, further these data indicate a new therapeutic for nasopharyngeal carcinoma by inhibiting HO-1 activity, which warrants further investigation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Shi, Lei" sort="Shi, Lei" uniqKey="Shi L" first="Lei" last="Shi">Lei Shi</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Fang, Jun" sort="Fang, Jun" uniqKey="Fang J" first="Jun" last="Fang">Jun Fang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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